Enabling formulations becomes more and more necessary to obtain adequate exposure of APIs during (pre)-clinical research. Currently, most registered formulations to improve bioavailability are based on lipidic systems, which make use of intrinsic digestion processes within the GI tract, facilitating the absorption of APIs. Aside from a general absorption mechanism, lipidic systems can also promote lymphatic transport of poorly soluble drugs, such as hormones. In addition, many different indications, such as HIV therapy, oncology, immunosuppressant and even arising therapies related to medicinal cannabis (e.g. CBD) can benefit from lipid formulations. These formulations create multiple possibilities for oral administration because they can be manufactured as solutions, suspensions, emulsions, and self-(micro)emulsifying systems.

During this webinar, Thermo Fisher Scientific's Kaspar van den Dries and Helena Teles will discuss potential mechanisms of increased absorption with lipid formulations and appropriate screening tools that are used during the development approach of these formulations. They will also cover subsequent steps to scale-up and industrialize these formulations.

Who Should Attend:

  • Head of CMC
  • Head of R&D
  • Head of Formulation
  • Senior Formulation Scientist
  • CMC Consultant

Featured Speakers

Kaspar van den Dries, Ph.D.

Senior Director Science and Innovations, Softgels
Thermo Fisher Scientific

In his current role, Dr. van den Dries provides direction to Thermo Fisher Scientific’s global research and development team in the development of innovative softgel formulations, processes and technologies to better meet the needs of pharmaceutical companies and patients. In addition, he supports the European network of development sites and sales representatives as technical lead on all oral formulations related to both solid dosages and softgel technologies in early and late stage development. 

Helena Teles

Formulation Development Manager
Thermo Fisher Scientific

Dr. Teles is leading the Formulation Development Department at the Thermo Fisher Scientific softgel site in the Netherlands in the formulation and process development of Soft Gelatin products and technologies. She leads projects in the field of poorly soluble compounds, self-emulsifying drug delivery systems, and delayed-release formulations.

Date:  Thursday, May 23, 2019
Time:  11am ET / 8am PT
Duration:  1 Hour

Register now for this webinar